Calculator your IPSS-R Score and IPSS-R Category

(g/dl). [4-20] A possible conversion for Hb values: 10 g/dL= 6.2 mmol/L, 8 g/dL= 5.0 mmol/L

(x109/L). [0-15]

(x109/L). [0-2000]

(percent). [0-30]

Calculate yourAge-Adjusted Risk (IPSS-RA) (only for survival estimation)

Years

Please Select a Differentiating Feature (only for survival estimation)

IPSS-R Score

IPSS-R Category

IPSS-RA Score

IPSS-RA Category (including age)

Revised International Prognostic Scoring System(IPSS-R) for Myelodysplastic Syndromes Risk Assessment Calculator

Advanced Calculator

Developed by the International Working Group for the Prognosis of MDS (IWG-PM) under the aegis of the MDS Foundation, Inc. When entering values into the calculator, note the units given in parentheses Also note that the usual ranges, given for orientation, are in brackets. These are not normal ranges.

IPSS-R Cytogenetic risk groups*,**

Cytogenetic prognostic subgroups Cytogenetic abnormalities
Very good -Y, del(11q)
Good Normal, del(5q), del(12p), del(20q), double including del(5q)
Intermediate del(7q), +8, +19, i(17q), any other single or double independent clones
Poor -7, inv(3)/t(3q)/del(3q), double including -7/del(7q), Complex: 3 abnormalities
Very poor Complex: >3 abnormalities

IPSS-R Prognostic Score Values*

Prognostic variable 0 0.5 1 1.5 2 3 4
Cytogenetics Very Good Good Intermediate Poor Very Poor
BM Blast % <=2 >2-<5% 5-10% >10%
Hemoglobin =>10 8-<10 <8
Platelets =>100 50-<100 <50
ANC =>0.8 <0.8

IPSS-R Prognostic Risk Categories/Scores*

RISK CATEGORY RISK SCORE
Very Low <=1.5
Low >1.5 - 3
Intermediate >3 - 4.5
High >4.5 - 6
Very High >6

IPSS-R: Prognostic Risk Category Clinical Outcomes*

No. pts Very Low Low Intermediate High Very High
Patients (%) 7012 19% 38% 20% 13% 10%
Survival*** 8.8 5.3 3.0 1.6 0.8
AML/25%***,^ NR 10.8 3.2 1.4 0.7

***Medians, years ^Median time to 25% AML evolution
*Greenberg, Tuechler, Schanz et al, Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndrome, Blood 120: 2454, 2012.
**Schanz J et al, J Clin Oncology 2012; 30:820